{"id": "package:11bf227f-1df5-40cf-9fdf-48c2028f827d", "name": "20 1201.pdf", "self_uri": "https://services.scicrunch.io/sparc/drs/v1/objects/11bf227f-1df5-40cf-9fdf-48c2028f827d", "size": 312199, "created_time": "2021-03-31T21:39:40,458738Z", "updated_time": "2021-05-26T21:03:34,456770Z", "version": "3", "mime_type": "application/pdf", "checksums": [{"checksum": "075db1b7e251c24446dc44efb45ab199dc02f0b0433baa146cdeae4982a19402", "type": "sha256"}], "access_methods": [{"type": "s3", "access_url": {"url": "s3://prd-sparc-discover50-use1/148/files/derivative/sub-ChAT-Gai-Male-Subject-3/20 1201.pdf"}, "region": "us-east-1"}], "dataset": {"id": "148", "doi": "DOI:10.26275/kj2u-2ukf", "title": "Chemogenetic activation or inhibition of cholinergic or nitrergic myenteric neurons of mouse colon", "description": "Contractile response to the chemogenetic activation or inhibition of distinct myenteric neuronal subsets", "abstract": "This dataset examines the effect of optogenetic activation of cholinergic and nitrergic myenteric neurons on motility of the colon, measured by simultaneous tension recordings of the proximal (pC), middle (mC) and distal colon (dC). We examined the effect of optically stimulating (stim) cholinergic and nitrergic neurons expressing the light-activated cation channel channelrhodopsin (ChR2) during a period of tonic inhibition, in between spontaneous colonic migrating motor complexes or CMMCs."}}