{"id": "package:4ca92407-12dc-4399-be96-b68f71ddb851", "name": "5R_jank258.tiff", "self_uri": "https://services.scicrunch.io/sparc/drs/v1/objects/4ca92407-12dc-4399-be96-b68f71ddb851", "size": 120825, "created_time": "2025-05-18T21:06:09,890808Z", "updated_time": "2025-05-18T21:06:36,980607Z", "version": "1", "mime_type": "image/tiff", "checksums": [{"checksum": "05fb22724593ab675b891721ee808ef0", "type": "sha256"}], "access_methods": [{"type": "s3", "access_url": {"url": "s3://sparc-prod-aod-discover-publish50-use1/544/files/code/motion_correction/5Rjanktiff/5R_jank258.tiff"}, "region": "us-east-1"}], "dataset": {"id": "544", "doi": "DOI:10.26275/u5yy-gi6w", "title": "Computational modeling of human vagus nerve stimulation with three-dimensional fascicular morphology", "description": "Computational models of human vagus nerve stimulation using true three-dimensional and extruded representations of nerve morphology.", "abstract": "To create computational models of human vagus nerve stimulation (VNS) that capture the nerve’s 3D fascicular morphology from microCT imaging. To compare these true-3D models to traditional extrusion models, thereby informing appropriate modeling methods for design and optimization of VNS therapies. Data were collected by performing computational simulations using true-3D and extrusion models of human vagus nerves. Segmented microCT images of human cervical vagus nerves provided anatomical inputs for true-3D model construction, and cross sections from the true-3D models provided anatomical inputs for extrusion model construction. We compared fiber-specific activation thresholds, dose-response relationships, recruitment order, and spatial selectivity across varying electrode configurations and stimulation parameters. Extrusion models of human vagus nerve stimulation can replicate true-3D neural responses if appropriately parameterized with nerve deformation and slice selection. True-3D modeling provides anatomical realism when capturing effects of fascicle merges and splits is important."}}