{"id": "package:5351601e-c92c-47bd-9d2b-9a62d3c5560a", "name": "Phenol all GPs PAGPx LAGPx RAGPx IVC-IAGPx VIVGPx RCVNS 10Hz 1ms 1.5mA A pacing 500ms.txt", "self_uri": "https://services.scicrunch.io/sparc/drs/v1/objects/5351601e-c92c-47bd-9d2b-9a62d3c5560a", "size": 29083881, "created_time": "2021-08-23T15:50:11,091644Z", "updated_time": "2021-08-23T15:50:12,947524Z", "version": "1", "mime_type": "text/plain", "checksums": [{"checksum": "2de8e49a531089aef0c91486bc54245f89bbef6aaaa41eb53bd28b46a2c7b68a", "type": "sha256"}], "access_methods": [{"type": "s3", "access_url": {"url": "s3://prd-sparc-discover50-use1/237/files/primary/sub-P1510/perf-P1510-Cardiac-Electrophysiology/Phenol all GPs PAGPx LAGPx RAGPx IVC-IAGPx VIVGPx RCVNS 10Hz 1ms 1.5mA A pacing 500ms.txt"}, "region": "us-east-1"}], "dataset": {"id": "237", "doi": "DOI:10.26275/rmkt-5ypu", "title": "Ablation of the intrinsic cardiac nervous system to evaluate efferent control of cardiac function", "description": "Sequential ablation of ganglionated plexuses of the intrinsic cardiac nervous system demonstrate control of cardiac electrophysiology and hemodynamics. Two different sequences of ablation are used to identify spheres of influence of efferent control.", "abstract": "In a Yucatan minipig model, sequential knockdown of cardiac ganglionated plexi (GPs) was performed to cause loss of function. Disruption of specific GPs of the intrinsic cardiac nervous system (ICN) was performed using an ultrasonic aspirator to define specific areas of influence with respect to neural control of cardiac mechanical and electrical function. Electrical autonomic (parasympathetic and sympathetic) stimulation were the primary methods of assessment for areas influenced by specific ICN ganglia as defined by regional loss of synchrony (electrical) following each successive GP ablation. GPs targeted include the right atrial GP (RAGP), posterior atrial GP (PAGP), inferior vena cava-inferior atrial GP (IVC-IAGP), left atrial GP (LAGP) and ventral intraventricular GP (VIVGP). Cardiac electrical activity was measured using a 56-electrode sock overlying the heart, and a pressure transducer catheter in the heart measured left ventricular pressures. Data were collected in Spike2 (.txt files) and using the GE CardioLab system (.txt files). Approximate number of files is 800 and size is 15GB."}}