{"id": "package:5367a79a-aa6b-4ae3-bdd5-28673d1c7068", "name": "5R_jank296.tiff", "self_uri": "https://services.scicrunch.io/sparc/drs/v1/objects/5367a79a-aa6b-4ae3-bdd5-28673d1c7068", "size": 120825, "created_time": "2025-05-18T21:06:26,854695Z", "updated_time": "2025-05-18T21:06:37,430277Z", "version": "1", "mime_type": "image/tiff", "checksums": [{"checksum": "9f1ccacae014c355062dda7a1184ba1c", "type": "sha256"}], "access_methods": [{"type": "s3", "access_url": {"url": "s3://sparc-prod-aod-discover-publish50-use1/544/files/code/motion_correction/5Rjanktiff/5R_jank296.tiff"}, "region": "us-east-1"}], "dataset": {"id": "544", "doi": "DOI:10.26275/u5yy-gi6w", "title": "Computational modeling of human vagus nerve stimulation with three-dimensional fascicular morphology", "description": "Computational models of human vagus nerve stimulation using true three-dimensional and extruded representations of nerve morphology.", "abstract": "To create computational models of human vagus nerve stimulation (VNS) that capture the nerve’s 3D fascicular morphology from microCT imaging. To compare these true-3D models to traditional extrusion models, thereby informing appropriate modeling methods for design and optimization of VNS therapies. Data were collected by performing computational simulations using true-3D and extrusion models of human vagus nerves. Segmented microCT images of human cervical vagus nerves provided anatomical inputs for true-3D model construction, and cross sections from the true-3D models provided anatomical inputs for extrusion model construction. We compared fiber-specific activation thresholds, dose-response relationships, recruitment order, and spatial selectivity across varying electrode configurations and stimulation parameters. Extrusion models of human vagus nerve stimulation can replicate true-3D neural responses if appropriately parameterized with nerve deformation and slice selection. True-3D modeling provides anatomical realism when capturing effects of fascicle merges and splits is important."}}