{"id": "package:5fdb9cd0-c88f-4f79-a83f-bb1f93b48291", "name": "Melanoma_RMS.m", "self_uri": "https://services.scicrunch.io/sparc/drs/v1/objects/5fdb9cd0-c88f-4f79-a83f-bb1f93b48291", "size": 1196, "created_time": "2024-06-24T14:29:30,023286Z", "updated_time": "2024-06-24T14:34:31,536241Z", "version": "1", "mime_type": "application/vnd.wolfram.mathematica.package", "checksums": [{"checksum": "efdf18a2fc119d50568170daeeb310a6", "type": "sha256"}], "access_methods": [{"type": "s3", "access_url": {"url": "s3://prd-sparc-discover50-use1/400/files/code/Melanoma_RMS.m"}, "region": "us-east-1"}], "dataset": {"id": "400", "doi": "DOI:10.26275/wlhm-9uyz", "title": "Neural recordings of spontaneously metastasizing melanomas and melanomas with low metastatic potential", "description": "Neural recordings of spontaneously metastasizing melanomas", "abstract": "To capture the in vivo, neural activity patterns within melanoma lesions as the cancer progresses through metastasis. We performed daily neural recordings from male and female mice bearing orthotopic metastasizing- melanomas and melanomas with low metastatic poential, derived from B16-F10 and B16-F1 cells, respectively. Our results show that metastasizing tumors display high levels of neural activity while tumors with low metastatic potential lack it indicating that the presence of neural activity is linked to the metastasizing potential of the tumors. Moreover, the neural activity is not continuous over the tumor progression and has a sex-specific temporal patterns where males have two peaks of high neural activity while females show a single peak. The neural peak activity originated in peripheral sympathetic nerves as sympathectomy completely eliminated the peak activity in both sexes."}}