{"id": "package:67a843d0-d6fc-41af-a1f1-6e38ef5a8191", "name": "Experiment_Primary_Feeding_Data_12195.xlsx", "self_uri": "https://services.scicrunch.io/sparc/drs/v1/objects/67a843d0-d6fc-41af-a1f1-6e38ef5a8191", "size": 17811, "created_time": "2023-10-04T22:56:19,279473Z", "updated_time": "2023-10-04T22:56:20,053995Z", "version": "1", "mime_type": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "checksums": [{"checksum": "aa9a88929e965ddc2919272d86b27051f84311f2f4ad51d30cdc131605b898b8", "type": "sha256"}], "access_methods": [{"type": "s3", "access_url": {"url": "s3://prd-sparc-discover50-use1/395/files/primary/sub-12195/Experiment_Primary_Feeding_Data_12195.xlsx"}, "region": "us-east-1"}], "dataset": {"id": "395", "doi": "DOI:10.26275/kbjd-ayv6", "title": "Evaluation of bilateral gastric electrical stimulation to improve energy balance regulation in female Sprague-Dawley rats consuming a 45% high-fat diet", "description": "Microstructural analysis of food intake as a behavioral endpoint to determine the effect of bilateral electrical stimulation of the forestomach on the consumption of a 45% high fat diet by female Sprague-Dawley rats.", "abstract": "To the best of our knowledge, electrical stimulation of the stomach has been limited to the ventral wall of the organ and found to be relatively ineffective at improving energy balance regulation in adult female Sprague-Dawley rats.  Unilateral stimulation of the ventral stomach wall ignores the fact that the vagus nerve innervates both the ventral and the dorsal walls of the stomach.  Thus, taking into account the bilateral innervation of the forestomach by the vagus nerve, we implanted two patch electrodes, one at each site on the ventral and the dorsal walls of the stomach that is known to contain the highest density of overlapping vagal terminals located in the circular and longitudinal muscle (i.e., intramuscular arrays).  Consumption of a 45% high-fat maintenance diet while the stomach was stimulated both bilaterally and unilaterally was recorded to determine if there was an improvement in energy balance regulation to this high-fat diet challenge. Microstructural analysis of food intake as a behavioral endpoint to determine the effect of bilateral electrical stimulation of the forestomach on the consumption of a 45% high fat diet by female Sprague-Dawley rats. The body weight and food intake of the unstimulated female shams did not differ from those of the stimulated female rats under the conditions tested (i.e., bilateral and unilateral stimulation of the stomach walls). The stimulated and unstimulated sham groups had similar blood glucose levels at the completion of the study."}}