{"id": "package:6b261532-bddf-4ec9-8d25-99683fb87e20", "name": "perf-R8-5454ML.xlsx", "self_uri": "https://services.scicrunch.io/sparc/drs/v1/objects/6b261532-bddf-4ec9-8d25-99683fb87e20", "size": 10745, "created_time": "2024-09-27T20:01:51,296414Z", "updated_time": "2024-09-27T20:02:31,568646Z", "version": "1", "mime_type": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "checksums": [{"checksum": "cad72f5f0f65770c4e6483f8cf8d3990", "type": "sha256"}], "access_methods": [{"type": "s3", "access_url": {"url": "s3://prd-sparc-discover50-use1/416/files/primary/sub-R8/perf-R8-5454ML/perf-R8-5454ML.xlsx"}, "region": "us-east-1"}], "dataset": {"id": "416", "doi": "DOI:10.26275/aexe-anbk", "title": "Temporal patterns of spinal cord stimulation for chronic pain in rat model", "description": "The purpose of this study was to design patterns of dual frequency spinal cord stimulation and test their ability to alleviate chronic pain in a rat model, specifically as compared with conventional spinal cord stimulation.", "abstract": "The purpose of this study was to design patterns of dual frequency spinal cord stimulation and test their ability to alleviate chronic pain in a rat model. Specifically, we sought to evaluate their performance relative to traditional, single frequency spinal cord stimulation. We used a biophysically validated computational model of the dorsal horn of the spinal cord to find dual frequency pairs that were likely to improve over single frequency counterparts and that the improvement was robust to pain progression and dorsal column fibers recruited. We tested these patterns in a spared nerve injured rat by recording paw withdrawal thresholds during stimulation. Dual frequency spinal cord stimulation in the spared nerve injury model of chronic pain increases responder rates to spinal cord stimulation over traditional single frequency stimulation."}}