{"id": "package:7f792447-b458-4adf-8bcc-2e96229cd877", "name": "1c. Telemetry_Tcore_activity_PBS_CNO_30C_10C.xlsx", "self_uri": "https://services.scicrunch.io/sparc/drs/v1/objects/7f792447-b458-4adf-8bcc-2e96229cd877", "size": 134293, "created_time": "2020-11-30T14:56:19,279451Z", "updated_time": "2021-04-11T19:34:26,205327Z", "version": "1", "mime_type": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "checksums": [{"checksum": "6c8de306cd4adb4d5b639984e6a03b8fc82929e9db0dbac52f2d117578afcf06", "type": "sha256"}], "access_methods": [{"type": "s3", "access_url": {"url": "s3://prd-sparc-discover50-use1/127/files/primary/pool-1/1c. Telemetry_Tcore_activity_PBS_CNO_30C_10C.xlsx"}, "region": "us-east-1"}], "dataset": {"id": "127", "doi": "DOI:10.26275/tuof-9odl", "title": "Chemogenetic iBAT (interscapular brown adipose tissue)-specific sympathetic stimulation and e-mitter implant in mice", "description": "Chemogenetic iBAT-specific sympathetic stimulation and e-mitter implant", "abstract": "Our data show the isolated stimulation of iBAT sympathetics results in an acute suppression of body temperature. Even though these data were surprising, they are consistent with our observations to manipulate b3-adrenergic receptors with an antagonist (CL-316,243) or agonist (SR 59230A).\n\nChemogenetics -/+ b3-adrenergic antagonist: Blockade of b3-adrenergic receptors enhances the suppression of core temperature with chemogenetic activation of iBAT sympathetics, consistent with the idea that isolated activation of iBAT sympathetic (in the absence of iWAT b3-AR activation) has an inhibitory effect on BAT thermogenesis.\n\nChemogenetics -/+ b3-adrenergic agonist: Activation of b3-AR receptors enhance the induction of core temperature and weight loss (independent of food intake). Taken together these data suggest that activation of iBAT has a bidirectional function that depends on b3-AR stimulation elsewhere (e.g. stimulation of white adipose tissue depots)."}}