{"id": "package:847bd54d-1e09-4c1e-98f8-f1f34543fd19", "name": "E060722_12_FVol.mat", "self_uri": "https://services.scicrunch.io/sparc/drs/v1/objects/847bd54d-1e09-4c1e-98f8-f1f34543fd19", "size": 2466700, "created_time": "2023-09-08T14:39:52,445502Z", "updated_time": "2023-09-08T14:40:49,238609Z", "version": "1", "mime_type": "application/x-matlab-data", "checksums": [{"checksum": "51e67f5129a094b58e5240cae88897cf", "type": "sha256"}], "access_methods": [{"type": "s3", "access_url": {"url": "s3://prd-sparc-discover50-use1/357/files/primary/sub-E060722/perf-E060722-12/E060722_12_FVol.mat"}, "region": "us-east-1"}], "dataset": {"id": "357", "doi": "DOI:10.26275/jh8n-lwdl", "title": "Reflex voiding in rat occurs at consistent bladder volume regardless of pressure or infusion rate", "description": "Single-fill supra-pubic cystometry in female Sprague-Dawley rats using infusion rates that span the range 0.92-65.5 ml/hr.", "abstract": "This study was conducted to determine what state variables (bladder pressure or volume) the central nervous system uses to activate the micturition and guarding reflexes. The activation of the micturition and guarding reflexes was observed during open outlet cystometry across many bladder infusion rates. For an individual animal, 10 rates were sampled at least 3 times in a pseudorandom fashion. Infusion rates ranged from 0.92-65.5 ml/hr. Bladder pressure and external urethral sphincter electromyography (EUS EMG) were used to identify the onset of the micturition and guarding reflexes respectively. Bladder volume was estimated from the measures of voided volume, residual volume, and infused volume. The micturition reflex was activated at constant volumes across many infusion rates indicating that the central nervous system uses volume to activate the micturition reflex. The central nervous system may use bladder pressure to activate the guading reflex."}}