{"id": "package:a990ce81-65d5-4e65-8d82-f72aabbe8733", "name": "manifest.xlsx", "self_uri": "https://services.scicrunch.io/sparc/drs/v1/objects/a990ce81-65d5-4e65-8d82-f72aabbe8733", "size": 41379, "created_time": "2024-11-23T00:58:23,100742Z", "updated_time": "2024-11-23T01:03:55,115114Z", "version": "1", "mime_type": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "checksums": [{"checksum": "9f8b2755ff75b15980a8b85638903b8a", "type": "sha256"}], "access_methods": [{"type": "s3", "access_url": {"url": "s3://prd-sparc-discover50-use1/419/files/primary/manifest.xlsx"}, "region": "us-east-1"}], "dataset": {"id": "419", "doi": "DOI:10.26275/ol8k-rau8", "title": "Intrinsic tongue muscle in a mouse model of Down syndrome", "description": "This dataset contains high-resolution images of one entire tissue section of the intrinsic tongue of each mouse. The sections have been stained to label markers of myofiber biology.", "abstract": "This study was conducted to discover anatomical markers of postnatal maturation of the intrinsic tongue muscles, and to identify how Down syndrome impacts this maturation The data is comprised of 20x composite images of one entire saggital intrinsic tongue section from each mouse in the study. Ts65Dn mice show microanatomical differences of the intrinsic tongue muscles compared to euploid controls. In both Ts65Dn and controls, microanatomical measures of myofiber size and Myosin Heavy Chain (MyHC) isoform profiles are significantly impacted by maturational age."}}