{"id": "package:b92152ca-f5fd-4ab7-b180-08738f44be33", "name": "rmssdHR.m", "self_uri": "https://services.scicrunch.io/sparc/drs/v1/objects/b92152ca-f5fd-4ab7-b180-08738f44be33", "size": 483, "created_time": "2022-12-14T16:32:08,914818Z", "updated_time": "2022-12-14T16:32:09,197899Z", "version": "1", "mime_type": "application/vnd.wolfram.mathematica.package", "checksums": [{"checksum": "787166d627f05a71ae659bd3fec7bbbc0a7cd16e2bd3abe2fa1aafb4160c914e", "type": "sha256"}], "access_methods": [{"type": "s3", "access_url": {"url": "s3://prd-sparc-discover50-use1/375/files/code/rmssdHR.m"}, "region": "us-east-1"}], "dataset": {"id": "375", "doi": "DOI:10.26275/eauv-gxwl", "title": "Electrocardiogram recordings in mice during vagus nerve stimulation", "description": "Acute physiological data describing heart rate modulation during VNS at different burst patterns and frequencies. this includes raw ECG files and quantified outcomes.", "abstract": "Purpose of this study was to assess how acute physiological effects of VNS. Heart rate change is a useful proxy for therapy of VNS. It is critical to understand how VNS parameter choice affects heart rate. Parametric testing can be used to inform parameter choice to increase therapeutic effects and leveraged to build computational models. We performed acute in vivo experiments in anesthetized mice where we collected ECG by the vagus nerve. We designed a tested a series of constant frequency and burst patterns of stimulation. We quantified heart rate changes using ECG. ECG is sensitive to stimulation amplitude, intra-burst frequency, and mean pulse rate."}}