{"id": "package:d2f87df8-ffb0-4be8-8310-fd8e716d343d", "name": "manifest.xlsx", "self_uri": "https://services.scicrunch.io/sparc/drs/v1/objects/d2f87df8-ffb0-4be8-8310-fd8e716d343d", "size": 9609, "created_time": "2022-03-03T03:21:26,182978Z", "updated_time": "2022-03-03T03:21:26,840657Z", "version": "7", "mime_type": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "checksums": [{"checksum": "f90edbcd654cc7d29ef1a5a72ae56a90c56ff0e830b11a9878069a62eec2fd7b", "type": "sha256"}], "access_methods": [{"type": "s3", "access_url": {"url": "s3://prd-sparc-discover50-use1/135/files/primary/manifest.xlsx"}, "region": "us-east-1"}], "dataset": {"id": "135", "doi": "DOI:10.26275/je6r-kbu8", "title": "Computational analysis of the human sinus node action potential - Model development and effects of mutations", "description": "CellML version of the Fabbri et al. 2017 mathematical model of the spontaneous electrical activity of a human sinoatrial node (SAN) pacemaker cell", "abstract": "Fabbri et al. constructed a comprehensive mathematical model of the spontaneous electrical activity of a human sinoatrial node (SAN) pacemaker cell, starting from the recent Severi–DiFrancesco model of rabbit SAN cells. The model is based on electrophysiological data from isolated human SAN pacemaker cells and closely matches the action potentials and calcium transient that were recorded experimentally. Simulated ion channelopathies explain the clinically observed changes in heart rate in corresponding mutation carriers, providing independent qualitative validation of the model. The model shows that the modulatory role of the ‘funny current’ (If) in the pacing rate of human SAN pacemaker cells is highly similar to that of rabbit SAN cells, despite its considerably lower amplitude. The model may prove useful in the design of experiments and the development of heart‐rate modulating drugs."}}