{"id": "package:de9e1fb5-01e9-45b2-ac8d-21077037bd5b", "name": "S1-10HzPreDuringAfter.mat", "self_uri": "https://services.scicrunch.io/sparc/drs/v1/objects/de9e1fb5-01e9-45b2-ac8d-21077037bd5b", "size": 2044006, "created_time": "2022-04-20T04:01:46,393344Z", "updated_time": "2022-04-27T18:29:48,024370Z", "version": "1", "mime_type": "application/x-matlab-data", "checksums": [{"checksum": "9df06677d8dd516bd20ff92d683089d85e2a32928e2c10c74c665d0d0803139f", "type": "sha256"}], "access_methods": [{"type": "s3", "access_url": {"url": "s3://prd-sparc-discover50-use1/243/files/primary/sub-M1/sam-S1/S1-10HzPreDuringAfter.mat"}, "region": "us-east-1"}], "dataset": {"id": "243", "doi": "DOI:10.26275/36ua-upkq", "title": "Dorsal root ganglion stimulation to modulate mechanosensitive colorectal afferent transmission in mice", "description": "DRG stimulation on colorectum-DRG-dorsal root preparation", "abstract": "The objective of this study is to determine the parameters of electrical stimulation of the dorsal root ganglia (L6 in mice) that reversibly blocks visceral afferent neural transmission. The dataset consists of functional responses of colorectal afferents to mechanical stimuli applied to the attached colorectum in an ex vivo preparation with colorectum, pelvic nerve, DRG and dorsal root in continuity. Electrical stimulation was delivered to the DRG to assess the blocking effect of colorectal afferent neural transmission. Sub-kilohertz DRG stimulation significantly attenuates colorectal afferent transmission (10, 50, 100, 500 and 1000 Hz), of which 50 and 100 Hz show superior blocking effects."}}