{"id": "package:e0f1308d-476c-4224-9cae-642f503fa98b", "name": "settings.xml", "self_uri": "https://services.scicrunch.io/sparc/drs/v1/objects/e0f1308d-476c-4224-9cae-642f503fa98b", "size": 16191, "created_time": "2025-03-21T19:10:00,108138Z", "updated_time": "2025-04-05T15:15:39,447984Z", "version": "1", "mime_type": "text/xml", "checksums": [{"checksum": "98a9ee4d44d0844d79bb0a5ac17de0ce", "type": "sha256"}], "access_methods": [{"type": "s3", "access_url": {"url": "s3://prd-sparc-discover50-use1/436/files/primary/female/sub-20-2023-02-22/perf-4-2023-02-22-ExtendedWithPause130/17-23-17-Amp-47-PW-300-Freq-100/PilotExpt53-230222-172719/settings.xml"}, "region": "us-east-1"}], "dataset": {"id": "436", "doi": "DOI:10.26275/orci-b0oq", "title": "Tonic stimulation of dorsal root ganglion results in progressive decline in recruitment of Aα and Aβ-fibers in rats", "description": "Electrophysiological data from Ting JE, et al. Tonic Stimulation of Dorsal Root Ganglion Results in Progressive Decline in Recruitment of Aα/β-Fibers in Rats. Neuromodulation. 2024 Dec;27(8):1347-1359. DOI: 10.1016/j.neurom.2024.06.498.", "abstract": "In this study, we aimed to characterize the recruitment and maintenance of action potential firing in Aα/β-fibers generated during tonic dorsal root ganglion stimulation (DRGS) applied over a range of clinically relevant stimulation parameters. We delivered electrical stimulation to the L5 dorsal root ganglion and recorded antidromic evoked compound action potentials (ECAPs) in the sciatic nerve during DRGS in Sprague Dawley rats. We measured charge thresholds to elicit ECAPs in Aα/β-fibers during DRGS applied at multiple pulse widths (50, 150, 300, 500 μs) and frequencies (5, 20, 50, 100 Hz). We measured the peak-to-peak amplitudes, latencies, and widths of ECAPs generated during 180 seconds of DRGS, and excitation threshold changes to investigate potential mechanisms of ECAP suppression. DRGS produces a progressive and frequency-dependent reduction in ECAP amplitude that occurs within and above the frequency range used clinically to relieve pain. If DRGS-mediated analgesia relies on Aβ-fiber activation, then the frequency or duty cycle of stimulation should be set to the lowest effective level to maintain sufficient activation of Aβ-fibers."}}