{"id": "package:f142f0b1-777f-4f31-bf93-d2c528ec4382", "name": "huffman_mice_in_vivo_data.mat", "self_uri": "https://services.scicrunch.io/sparc/drs/v1/objects/f142f0b1-777f-4f31-bf93-d2c528ec4382", "size": 2351, "created_time": "2023-01-29T13:56:02,066834Z", "updated_time": "2023-01-29T13:56:40,732056Z", "version": "4", "mime_type": "application/x-matlab-data", "checksums": [{"checksum": "1aba9630c6c84f3f92d8db6092b4227f", "type": "sha256"}], "access_methods": [{"type": "s3", "access_url": {"url": "s3://prd-sparc-discover50-use1/306/files/code/huffman_mice_in_vivo_data.mat"}, "region": "us-east-1"}], "dataset": {"id": "306", "doi": "DOI:10.26275/ek3b-zvut", "title": "Computational model of vagus nerve stimulation in mice with bipolar cuff electrode", "description": "Computational model of vagus nerve stimulation in mice with a bipolar cuff electrode, built with ASCENT v1.1.4, using a generalized nerve morphology.", "abstract": "To implement, simulate, and analyze a computational model of mouse VNS with the MicroLeads bipolar cuff electrode to complement in vivo experiments which recorded laryngeal EMG and heart rate during stimulation. We used ASCENT v1.1.4 to build a 3D model of a mouse vagus nerves instrumented with the MicroLeads bipolar cuff electrode. We simulated thresholds for 2-5 um “B” and 7-11 um “A alpha” fibers, which we compared to heart rate and laryngeal EMG in vivo responses, respectively. The model accurately predicted thresholds for A fiber onset/saturation and B fiber onset, and underestimated B fiber saturation. Recruitment order of the fibers was driven by longitudinal fiber alignment for A fibers and fiber diameter for B fibers."}}